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The following abstracts represent the research that will be presented by the Bing Center at the ASH 2023 meeting, December 9-12, 2023 in San Diego. For more information about the ASH 2023 meeting, please visit https://www.hematology.org/meetings/annual-meeting.

Quantitative MYD88 L265P Analysis Represents a Powerful Tool for Assessing Disease Response and Evaluating Clinical Trial Performance in Waldenstrom's Macroglobulinemia

Nickolas Tsakmaklis, BA, Zachary R Hunter, PhD, Xia Liu, MD, Amanda Kofides1, Shirong Liu, MD, PhD, Alexa G Canning, BA, Kris Richardson, PhD, Maria Luisa Guerrera, MD, Christopher J Patterson1, Kirsten Meid, MPH, Timothy P. White1, Megan Little, Katherine Stockman, Joshua Gustine, MD, MPH, Catherine A. Flynn, NP, Andrew R. Branagan, MD, Shayna R Sarosiek, Jorge J. Castillo, MD and Steven P. Treon, MD, PhD, FRCP

Prospective Study of Acalabrutinib with Rituximab in Patients with Symptomatic Anti-MAG Mediated IgM Peripheral Neuropathy

Shayna R Sarosiek, Andrew R. Branagan, MD, Christopher Doughty, Catherine A. Flynn, NP, Megan Little, Katherine Stockman, Timothy P. White, Kirsten Meid, MPH, Steven P. Treon, MD, PhD, FRCP and Jorge J. Castillo, MD

CD19-Targeting CAR T-Cell Therapy in Transformed Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma: A Descar-T and US Collaborative Study

Eric Durot, Damien Roos-Weil, Adrien Chauchet, Justine Decroocq, MD, Roberta Di Blasi, MD, PhD, Thomas Gastinne, MD, Hedi Bensader, Morgane Cheminant, Caroline Jacquet, MD, Stephanie Guidez, François-Xavier Gros, Emmanuel Bachy, MD, PhD, Pascale Cony-Makhoul, MD, Steven P. Treon, MD, PhD, FRCP, Alain Jacques Delmer, MD, Ran Reshef, MD, MSc, Steven Le Gouill, MD, PhD, Jorge J. Castillo, MD and Roch Houot, MD, PhD

Changes in Methylation and Chromatin Accessibility Underlie Subtype Classification and Disease Evolution in Waldenstrom's Macroglobulinemia

Zachary R Hunter, PhD, Nickolas Tsakmaklis, BA, Kris Richardson, PhD, Maria Luisa Guerrera, MD, Amanda Kofides, Xia Liu, MD, Shirong Liu, MD, PhD, Catherine A. Flynn, NP, Kirsten Meid, MPH, Christopher J Patterson, Mariateresa Fulciniti, PhD, Mehmet K. Samur, PhD, Kenneth C. Anderson, MD, Nikhil C Munshi, MD, Shayna R Sarosiek1, Jorge J. Castillo, MD, Ari M Melnick, MD and Steven P. Treon, MD, PhD, FRCP

Atypical Stem Cell, Pre-B-Cell, T-Cell and Myeloid Gene Expression Characterizes Early Waldenstrom's Macroglobulinemia Clones Which Diminishes with Advancing Disease and Has Therapeutic Implications

Zachary R Hunter, PhD, Maria Luisa Guerrera, MD, Ruben D. Carrasco, MD, PhD, Nickolas Tsakmaklis, BA, Kris Richardson, PhD, Amanda Kofides, Xia Liu, MD, Shirong Liu, MD, PhD, Catherine A. Flynn, NP, Kirsten Meid, MPH, Joshua Gustine, MD, MPH, Christopher J Patterson, Mariateresa Fulciniti, PhD, Mehmet K. Samur, PhD, Tomasz Sewastianik, MSc, PhD, Kenneth C. Anderson, MD, Nikhil C Munshi, MD, Shayna R Sarosiek1, Jorge J. Castillo, MD and Steven P. Treon, MD, PhD, FRCP

Ibrutinib and Venetoclax in Symptomatic, Treatment-Naive Patients with Waldenström Macroglobulinemia

Jorge J. Castillo, MD, Shayna R Sarosiek1, Andrew R. Branagan, MD, Catherine A. Flynn, NP, Megan Little, Katherine Stockman, Timothy P. White, Alexandra N. Eurell, Maria Luisa Guerrera, MD, Amanda Kofides, Shirong Liu, MD, PhD, Xia Liu, MD, Kris Richardson, PhD, Nickolas Tsakmaklis, BA, Kirsten Meid, MPH, Christopher J Patterson, Zachary R Hunter, PhD and Steven P. Treon, MD, PhD, FRCP

Novel Isoforms Identified By Isoseq Analysis Drive Expression Differences in Key Genes That Delineate the Subtypes of Waldenstrom's Macroglobulinemia

Kris Richardson, PhD, Nickolas Tsakmaklis, BA, Maria Luisa Guerrera, MD, Amanda Kofides, Xia Liu, MD, Shirong Liu, MD, PhD, Catherine A. Flynn, NP, Kirsten Meid, MPH, Christopher J Patterson, Mariateresa Fulciniti, PhD, Mehmet K. Samur, PhD, Kenneth C. Anderson, MD, Nikhil C Munshi, MD, Shayna R Sarosiek1, Jorge J. Castillo, MD, Zachary R Hunter, PhD and Steven P. Treon, MD, PhD, FRCP

Early Subclones Showing Aberrant Co-Expression of Stem Cell, T Cell and Myeloid Genes Can be Detected By Flow Cytometry in MYD88 Mutated Waldenstrom's Macroglobulinemia Patients

Maria Luisa Guerrera, MD, Amanda Kofides, Xia Liu, MD, Nickolas Tsakmaklis, BA, Kris Richardson, PhD, Shirong Liu, MD, PhD, Christopher J Patterson, Catherine A. Flynn, NP, Kirsten Meid, MPH, Nikhil C Munshi, MD, Kenneth C. Anderson, MD, Shayna R Sarosiek1, Jorge J. Castillo, MD, Steven P. Treon, MD, PhD, FRCP and Zachary R Hunter, PhD

Single-Cell RNA Sequencing Reveals Hypo-Responsiveness of T and NK Cells to Interferon Stimulation As an Immune Hallmark in Asymptomatic Waldenstrom's Macroglobulinemia

Yoshinobu Konishi, MD, PhD, Romanos Sklavenitis-Pistofidis, MD, Daniel L. Mallory, BS, Ting Wu, MS, Michelle P. Aranha, PhD, Junko Tsuji, PhD, Nicholas J Haradhvala, PhD, Elizabeth D. Lightbody, PhD, Katherine Towle, BS, Laura Hevenor, BS, Nickolas Tsakmaklis, BA, Xiyue Wang, BS, Alexa G Canning, BA, Christine-Ivy Liacos, MS, Efstathios Kastritis, MD, Meletios A. Dimopoulos, Steven P. Treon, MD, PhD, FRCP, Gady Getz, PhD and Irene M. Ghobrial, MD

Modified Staging System for Waldenstrom's Macroglobulinemia (MSS-WM): A Multi-Institutional Externally Validated Prognostic Model for Active/Symptomatic Waldenstrom's Macroglobulinemia

Saurabh Zanwar, MD, MBBS, Jennifer Le-Rademacher, Ph.D., Eric Durot, Shirley D'Sa, Jithma Prasad Abeykoon, MD, Patrizia Mondello, MD, PhD, MSc, Shaji Kunnathu Kumar, MD, Shayna R Sarosiek, Jonas Paludo, MD, Saurabh Chhabra, MD, Joselle Cook, MBBS, Ricardo Parrondo, MD, Angela Dispenzieri, MD, Wilson I. Gonsalves, MD, Eli Muchtar, MD, Sikander Ailawadhi, MD, Robert Kyle, MD, Vincent Rajkumar, MD, Alain Jacques Delmer, MD, Rafael Fonseca, MD, Morie A. Gertz, MD, Steven P. Treon, MD, PhD, FRCP, Stephen M Ansell, MD, PhD, Jorge J. Castillo, MD and Prshant Kapoor, MD

Novel Protacs Demonstrate Dual Kinase Inhibition and Degradation of HCK and BTK, and Are Highly Active in MYD88 Mutated WM and ABC DLBCL Cells

Shirong Liu, MD, PhD, John M Hatcher, PhD, Amanda Kofides, Alexa G Canning, BA, Jinhua Wang, PhD, Xia Liu, MD, Nickolas Tsakmaklis, BA, Maria Luisa Guerrera, MD, Christopher J Patterson, Zachary R Hunter, PhD, Shayna R Sarosiek, Jorge J. Castillo, MD, Sara J. Buhrlage, PhD and Steven P. Treon, MD, PhD, FRCP

Pacritinib Blocks Key Pro-Survival Signaling Related to Mutated MYD88, Produces High Levels of Apoptosis and Overcomes Mutated BTKCys481 Related BTK-Inhibitor Resistance

Shirong Liu, MD, PhD, Amanda Kofides, Xia Liu, MD, Alexa G Canning, BA, Nickolas Tsakmaklis, BA, Maria Luisa Guerrera, MD, Christopher J Patterson, Zachary R Hunter, PhD, Kris Richardson, PhD, Catherine A. Flynn, NP, Kirsten Meid, MPH, Megan Little, Katherine Stockman, Timothy P. White, Shayna R Sarosiek, Jorge J. Castillo, MD and Steven P. Treon, MD, PhD, FRCP

Aberrant Expression of Spliced WNK2 Is an Early Event in MYD88 Mutated WM That Activates ERK1/2 and Supports Tumor Growth

Maria Luisa Guerrera, MD, Zachary R Hunter, PhD, Kris Richardson, PhD, Nickolas Tsakmaklis, BA, Amanda Kofides, Shirong Liu, MD, PhD, Christopher J Patterson, Eugenio Morelli, MD, Jorge J. Castillo, MD, Shayna R Sarosiek, Catherine A. Flynn, NP, Kirsten Meid, MPH, Andrew R. Branagan, MD, Ruben D. Carrasco, MD, PhD, Kenneth C. Anderson, MD, Nikhil C Munshi, MD, Steven P. Treon, MD, PhD, FRCP and Xia Liu, MD