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After completing my training in Hematology and Oncology, I stayed as a Faculty member at the Brown University Medical School spending 60% of my time doing clinical care, 30% clinical research and 10% teaching. My research has focused on studying the various risk factors that could be associated with an increased risk of developing hematologic malignancies. I have also run a series of investigator-initiated prospective clinical trials using non-chemotherapeutic regimens, and have developed several multi-institutional efforts to study rare lymphomas such as plasmablastic lymphoma and HIV-associated T-cell lymphomas. Finally, I have helped and mentored Peruvian colleagues to design studies suitable for publication in English literature.

My most successful area has been epidemiological research; I have used meta-analytical methods to gather the existing body of evidence and identified cigarette smoking as a risk factor for Hodgkin lymphoma, and red blood cell transfusions for chronic lymphocytic leukemia. Also, using a similar method, I was able to demonstrate an increased risk of leukemia, lymphoma and myeloma in individuals with diabetes. This work has been published in high-impact factor journals such as Blood and the Journal of Clinical Oncology. I believe that there are many things to learn from the studies that have already been done, if the systematic reviews and subsequent meta-analyses are carefully designed.

The accrual for one of my non-chemotherapy prospective studies has been completed and will work on an abstract presentation and subsequent manuscript. My work on rare lymphomas has been published in journals such as Cancer, The Oncologist, Leukemia and Lymphoma and Leukemia Research, and has been very well cited despite the rarity. This work has allowed me to generate an international collaborative network with participants from the United States, England, Spain, Italy, Brazil and Peru. I would like to think that I have increased the awareness towards these less well-understood conditions through collaboration. My work with Peruvian colleagues has been fruitful with close to 20 publications in the last 5 years.

I have spent a good amount of time mentoring colleagues, fellows, residents and medical students. Many of the trainees who have worked with me have been able to present their research at national meeting such as the American Society of Hematology Annual Meeting. Even after their graduation, I am proud to see that they continue doing meaningful research and I am always happy to help in any way possible with study design, statistical support or just pure and constructive criticism of their protocols and manuscripts.

My next steps will be to continue doing clinical research focusing more in the careful design and execution of prospective clinical trials, and the envision of potential systematic reviews and meta-analysis not only for epidemiological associations but also to evaluate therapeutic interventions. I will also continue mentoring colleagues and trainees at different levels while promoting international collaboration.

Please feel free to visit JorgeJCastillo.com where you will find more specific information on the Bing Center Clinic, as well as a more specific list of my technical publications.

Latest Bing Center News

Latest News in the Treatment of WM - TELECONFERENCE 3/19/2020

Latest News in the Treatment of WM - TELECONFERENCE 3/19/2020

CancerCare, in association with the IWMF, is holding a Teleconference titled –  The Latest News in the Treatment of Waldenstrom’s Macroglobulinemia on Thursday, March 19th  from 1:10-2:30  pm Eastern Time (ET). Presenting will be Steven Treon, MD, Ph.D, Christian Buske, MD, Carolyn Messner, DSW, OSW-C, FAPOS, FAOSW, and Carl Harrington (IWMF).

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25th Annual IWMF Educational Forum

25th Annual IWMF Educational Forum

25th Annual IWMF Educational ForumJune 5-7, 2020Renton, WA"2020 Vision: A World Without WM"

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Steven Treon, MD, PhD to serve as advisor to IWMF Board

Steven Treon, MD, PhD to serve as advisor to IWMF Board

Dr. Steven Treon, MD, PhD, (Dana-Farber Cancer Institute) has agreed to advise the IWMF Board of Trustees. Dr. Treon joins Dr. Ansell of the Mayo Clinic in providing the critical perspective of world-renowned clinicians/researchers to the IWMF Board. Dr. Treon and Dr. Ansell also will jointly co-chair the IWMF Scientific Advisory Committee.

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Florida Blood Cancer Conference 2020 (LLS)

Florida Blood Cancer Conference 2020 (LLS)

Dr. Steven Treon will be lecturing at the upcoming Blood Cancer Conference (BCC), one of many programs developed by The Leukemia & Lymphoma Society (LLS) to meet the needs of patients, survivors, families and oncology professionals, the people who deal with blood cancer every day and the people who care for them. BCC attendees receive the most current information and access to local resources to help navigate and make informed decisions about their treatment and survivorship.

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ASH 2019 - Bing Center Presentations

ASH 2019 - Bing Center Presentations

The ASH 2019 conference was held in Orlando, FL from December 7-10, 2019. Researchers from the Bing Center contributed an oral presentation (Guang Yang), and three posters (Jorge Castill, and Xia Liu).  

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IWMF Adds Three Members to Scientific Advisory Committee

IWMF Adds Three Members to Scientific Advisory Committee

The IWMF is proud to welcome three new members to its Scientific Advisory Committee (SAC) chaired by Dr. Stephen Ansell of the Mayo Clinic and Dr. Steven Treon of the Dana-Farber Cancer Institute. The new members, Dr. Zachary Hunter from Dana-Farber, Boston, USA, Dr. Christian Buske from Ulm, Germany, and Dr. Monique Minnema of The Netherlands, were invited to participate because of their expertise in specific research areas identified by the IWMF-LLS Strategic Research Roadmap for WM.

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Dr. Edward Laane - Running for WM! (Part-2)

Dr. Edward Laane - Running for WM! (Part-2)

On November3, 2019, Dr. Edward Laane ran the Osaka Yodo River Half Marathon, to raise money for Waldenstrom's research. His pure running time was 2.26.07 with his official time listed at 2.31.0. As Dr. Laane recalls, "The run was difficult. It was sunny, and a little bit hot. The first part, 6.5 miles was a little easier. My time was approximately 1h 10 min, but the second part was very difficult. But I was thinking about the patients who have gone through so much treatment and this gave me more strength to finish.

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New Approaches to treating Waldenstrom's Macroglobulinemia

New Approaches to treating Waldenstrom's Macroglobulinemia

At the 2019 Lymphoma & Myeloma Congress, Steven Treon, MD, PhD, FACP, FRCP, Harvard University, Dana-Farber Cancer Institute, Bing Center for Waldenström Macroglobulinemia, Boston, Massachusetts, provided an update on the latest research in the treatment of Waldenström Macroglobulinemia.

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Dr. Edward Laane - Running for WM!

Dr. Edward Laane - Running for WM!

Dr. Edward Laane is running in the Osaka Yodo River Citizens Marathon to raise money for Waldenstrom's research!

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IMW-17 Young Investigator Awards

IMW-17 Young Investigator Awards

Congratulations to the following Bing Center researchers for their Young Investigator Awards at the 17th International Workshop on Multiple Myeloma!

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