Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Manit joined the Bing Center in February 2017 after graduating from the University of Massachusetts, Amherst with a B.S. degree in Biochemistry and Molecular Biology and an M.S. degree in Molecular and Cellular Biology. At UMass, he spent 5 years working in an immunology lab with a focus on the Notch signaling pathway in Multiple Sclerosis. Manit is currently working with Dr. Guang Yang on a few drug development projects as well as a variety of other studies.

  Phone: 617-582-8235Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Amanda joined the Bing Center in September, 2016 and assists Dr. Lian Xu in processing samples of peripheral-blood and bone marrow of treated and untreated patients for the serum and gDNA banks. Her Bachelor of Science in Biology with a minor in Business, was received from Suffolk University. Her previous work in research featured reconstructing mammalian dietary ecology using dental microwear and craniodental morphology at the Department of Biology of Suffolk University. Amanda has received Young Investigator Awards from the 10th International Workshop on WM (IWWM-10) and the 17th International Myeloma Workshop (IMW-17).

  Phone: 617-632-5829Email: This email address is being protected from spambots. You need JavaScript enabled to view it. In February 2016, Maria joined the Dana-Farber Cancer Institute’s Bing Center for Waldenstrom’s Macroglobulinemia. Her Bachelor of Science in Biology was received from the University of Massachusetts Boston in 2014. Maria is one of our senior research technicians here at the Bing Center for WM. Aiding in both administrative and wet lab duties, Maria also has an independent projects in the works. Prior to her working with the Bing Center, she volunteered in the Microbiology lab on the University of Massachusetts’ campus, assisting in research pertaining to Sinohizobiummeliloti. Interests include nutrition, mental health, miniatures, arts and crafts. Maria is currently assisting in the Bing Center research lab processing samples for our serum and gDNA banks.

Phone: 617-582-9031Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Zachary Hunter has been with the Bing Center since 2003 and has worked on multiple organizational and scientific projects during that time. His current research involves characterizing the role of IgG and IgA deficiency in Waldenstom’s Macroglobulinemia, functional and clinical correlation analysis of mRNA and miRNA expression, and examining the clinical and genetic characteristics of families with a history of WM and other B-cell disorders. He holds a BA in mathematics from Haverford College, a MA in Pathology from Boston University, and a Ph.D. in Pathology from the Boston University School of Medicine, where his thesis research was with the Bing Center under Drs. Steven Treon of Dana-Farber and Christopher Andry of Boston University.

Email: This email address is being protected from spambots. You need JavaScript enabled to view it. In 2005, Xia Liu began work as a Senior Research Technician in the Department of Medical Oncology, Dana Farber Cancer Institute, Boston. Many project focuses involve suppressor cells and their function against autoimmune diseases. Xia joined the Bing Center for Waldenstrom’s Research, DFCI in July 2007. Now she is working on the pathogenesis of Waldenstrom’s macroglobulinemia. Mrs. Liu received her degrees in Medical Science in Shanghai, China. After graduation, she worked at the Shanghai Railway hospital as a physician and lecturer. In 1999, MRs. Liu focused her work in research at Ohio State University, later to aspire to Harvard University as a research assistant. She has been well trained in molecular and cellular biology, histology, immuno-histochemistry, and signal transductions. As she continues to work with Waldenstrom’s macroglobulinemia, her concentrations are focused on a pathogenesis level.

Phone: 617-632-2681Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Dr. Steven Treon is the Director of the Bing Center for Waldenström's Macroglobulinemia and an Attending Physician for the Department of Medical Oncology at the Dana-Farber Cancer Institute and Brigham and Women’s Hospital in Boston, Massachusetts. He is also a Professor of Medicine at Harvard Medical School in Boston, and is the Chair of the Waldenström's Macroglobulinemia Clinical Trials Group. Dr. Treon received a medical degree with honors from the Boston University School of Medicine, and a master’s degree in biochemistry and a doctorate of philosophy in tumor immunology from the graduate school at Boston University Medical Center. Dr Treon completed an internship and residency in internal medicine at Boston University Medical Center. He also completed a clinical fellowship in hematology and oncology at the Massachusetts General Hospital and a research fellowship at the Dana-Farber Cancer Institute and Harvard Medical School. He received certification from the American Board of Internal Medicine (ABIM) in Internal Medicine and Medical Oncology, and continues to maintain his ABIM certification in Medical Oncology. Dr. Treon’s research interests are focused on understanding the genetic basis and pathogenesis of Waldenström’s Macroglobulinemia (WM), and the development of targeted therapeutics for this malignancy. Using whole genome sequencing, the Treon laboratory discovered the highly prevalent MYD88 L265P and CXCR4 WHIM mutations in WM, permitting the development of diagnostic molecular testing and targeted treatments for WM. Signaling work performed in the Treon laboratory established the critical role of Bruton’s Tyrosine Kinase (BTK) as a key mediator of MYD88…

Phone: 617-582-7306Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Phil first joined the Bing Center for WM in late 2003 as a volunteer. He developed a software application that automated the manual data collection processes to support our various research projects, resulting in a 90% reduction of the data collection time required for these projects. He also maintained the Bing Center websites to support previous and upcoming conferences and research efforts. Since joining the staff in 2009, he continues to maintain existing websites, develop new websites and software applications, as well as provide specialized technical support for the research staff where needed. He also provides project management for our bi-annual Patient & Physician Summits and WM Workshops in the areas of graphics design, program books & other printed materials, conference A/V and keeping the presentations running smoothly. Phil has over 30 years of experience in the high tech industry as a software developer and project manager, particularly in the telecommunications area. He has a BS in Systems Engineering from Boston University, and holds a patent for the design of a digital teleconferencing system. Phil, his wife Kathy and their 2 birds (Baby & Carl) currently reside in Haverhill, MA, and enjoy visiting with their three other “kids”, Steve, Marissa, and Matt.

Nick joined our group in November, 2013, having recently graduated from Boston University with a degree in Neuroscience. At BU, he spent a year in an experimental psychology lab programming operant chambers while studying auditory memory in rats. Nick will act as an intern in the Bing Center, where he will be collecting and processing blood samples for storage in our serum bank, and assisting the team in various other research projects. Nick resides in Roslindale, where he spends his time playing basketball, watching movies, and reading the latest medical research journals.

Phone: 617-632-3875Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Lian Xu received her BS in chemical engineering from East China Institute of Chemical Technology in Shanghai, China. She came to USA in 1989 as a visiting graduate student at the University of North Carolina at Chapel Hill with a focus on biochemistry and molecular biology. Xu previously worked as a senior research assistant and research coordinator in the pediatrics department of UNC-CH and Children’s National Medical Center in Washington DC. She has also completed numerous graduate courses in molecular biology, cellular biology and computer science at NIH graduate school and Johns Hopkins University. Xu is now excited to apply her molecular biology experience to the WM Program, and to help advance research in the genetic basis, pathogenesis and evaluation of novel antibody- and vaccine-based immunotherapies for Waldenström’s macroglobulinemia. Mrs. Xu joined the Bing Center for Waldenstrom’s macroglobulinemia in 2003 and specializes in a variety of molecular and cell biology projects exclusively for Waldenstrom’s macroglobulinemia.

Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Phone: 617-632-5598 Kirsten joined the Bing Center for Waldenstrom’s macroglobulinemia, Dana Farber Cancer Institute in March 2013. She received her Bachelor of Arts in Pyschology and minors in Biology and Statistical Methods from Boston University in 2007, and completed her Masters of Public Health degree with concentrations in Epidemiology and Social and Behavioral Science at Boston University School of Public Health in 2009. Prior to working with the Bing center, she worked in clinical trials with the Lank Center for Genitourinary Oncology at DFCI. Kirsten is currently working on Bing Center related clinical trials opened by Dr. Treon and Dr. Castillo.

Email: This email address is being protected from spambots. You need JavaScript enabled to view it. After completing my training in Hematology and Oncology, I stayed as a Faculty member at the Brown University Medical School spending 60% of my time doing clinical care, 30% clinical research and 10% teaching. My research has focused on studying the various risk factors that could be associated with an increased risk of developing hematologic malignancies. I have also run a series of investigator-initiated prospective clinical trials using non-chemotherapeutic regimens, and have developed several multi-institutional efforts to study rare lymphomas such as plasmablastic lymphoma and HIV-associated T-cell lymphomas. Finally, I have helped and mentored Peruvian colleagues to design studies suitable for publication in English literature. My most successful area has been epidemiological research; I have used meta-analytical methods to gather the existing body of evidence and identified cigarette smoking as a risk factor for Hodgkin lymphoma, and red blood cell transfusions for chronic lymphocytic leukemia. Also, using a similar method, I was able to demonstrate an increased risk of leukemia, lymphoma and myeloma in individuals with diabetes. This work has been published in high-impact factor journals such as Blood and the Journal of Clinical Oncology. I believe that there are many things to learn from the studies that have already been done, if the systematic reviews and subsequent meta-analyses are carefully designed. The accrual for one of my non-chemotherapy prospective studies has been completed and will work on an abstract presentation and subsequent manuscript. My work on rare lymphomas has been published in journals such as Cancer, The…

Phone: 617-632-6964Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Dr. Guang Yang has joined as a research fellow with the Bing Center for Waldenstrom’s macroglobulinemia, Dana Farber Cancer Institute this past year. His education began in Beijing, China, earning him a PhD in Biochemistry and molecular biology. Dr Yang has been with the Dana Farber Cancer Institute since 2001, and with a diverse and strong background in biochemistry, molecular biology, immunology and cell biology. He is very proficient in antibody engineering, protein expression and purification, tumor antigen gene screening, RNA splicing and cell morphology research. He is a vital contributor to the Bing Center for Waldenstrom’s macroglobulinemia. Dr Yang is currently working on a variety of projects for the Bing Center for Waldenstrom’s macroglobulinemia. The following is a list of his current publications: Guang Yang, Shu-Ching Huang, Jane Y. Wu, and Edward J. Benz, Jr. Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation Blood, 1 January 2008, Vol. 111, No. 1, pp. 392-401. Yang G, Li Y, Nishimura EK, Xin H, Zhou A, Guo Y, Dong L, Denning MF, Nickoloff BJ, Cui R.. Inhibition of PAX3 by TGF-beta modulates melanocyte viability, Mol Cell, 2008, 32(4): 554-63. Guang Yang, Shu-Ching Huang, Jane Y. Wu, and Edward J. Benz, Jr. An erythroid differentiation–specific splicing switch in protein 4.1R mediated by the interaction of SF2/ASF with an exonic splicing enhancer Blood, 1 March 2005, Vol. 105, No. 5, pp. 2146-2153 Yang G, Ran YL, Sun LX, etc. High Expression in CHO Cells and Activity of an…

Phone: 617-632-6285Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Chris Patterson is the Administrative Director of the Bing Center for Waldenstrom’s Macroglobulinemia. After completing his undergraduate studies at Kings College, and the University of Heidelberg in Germany, Chris studied immunology and biochemistry at the Harvard University Extension School, Cambridge MA. In 2005, Chris joined the Bing Center as a Clinical Research Coordinator and was responsible for clinical trials examining the role of sildenafil, imatinib mesylate, and bortezomib in the treatment of Waldenstrom’s Macroglobulinemia. In 2007, he undertook the role of Administrative Director for the Bing Center, and led the expansion of the Bing Center Basic Science and Clinical Trial Efforts. In 2008, Chris served as the Secretariat of the highly successful 5th International Workshop on Waldenstrom’s Macroglobulinemia which took place in Stockholm, Sweden and attracted senior and young investigators from around the world for a 4 day scientific workshop on WM. For his efforts, Chris was honored at the closing ceremonies, which took part in the Nobel Hall. In 2009, Chris organized the 3rd International Summit on WM, which brought over 600 patients and physicians to Boston for a 3-day Summit on WM. In addition to his administrative roles, Chris has been a strong advocate for WM patient education, and is also the coordinator for the New England WM Support Group. He has organized numerous regional WM support group meetings throughout North America and Europe, including the 2009 Toronto Summit on WM. Among his research interests, Chris undertook studies addressing cholesterol and iron deficiency in WM,…